STS-125 (Atlantis) and back up Shuttle STS-400 (Endeavour) on the launch pad
This was the last planned manned mission to the Hubble Telescope until it is decommisioned. One of the crew's jobs was to attach a locking ring so that the telescope can be grabbed by a robot vehicle and directed into the atmosphere in a controlled way when its job is done. Because of the improved gyros the mission installed it should stay up a bit longer now, anyway.
So, that's almost it for Atlantis and the other two Shuttles, Endeavour and Discovery. They each have one more flight each next year before they are retired and then it's a four year wait before project Constellation delivers the Orion Spacecraft (basically a big Apollo module) and the Ares launcher. In the meantime Russian rockets will be used to service the International Space Station or, possibly, some of the American commercial concerns using the Falcon 9 and Taurus II rockets.